In the realm of digital pressure sensing, efficient communication protocols are indispensable for seamless integration into various applications. The Inter-Integrated Circuit (I2C) and Serial Peripheral Interface (SPI) protocols stand out as two widely adopted standards, offering flexible and reliable means of interfacing with digital pressure sensors. However, despite their prevalence, navigating the intricacies of these protocols can pose challenges for developers, especially those new to the field. To facilitate the implementation process and empower developers with practical insights, this application note delves into the fundamentals of I2C and SPI interfacing for digital pressure sensors, accompanied by comprehensive code examples. Through elucidating these protocols and providing hands-on examples, this document aims to streamline the integration process, enabling developers to leverage.